Monday, March 13, 2017

3D Printing Organs

Paul Hoskins
Bio 1610 Sec 008
13/Mar/2017

                3-D printing is still considered a new technology but the applications for it are still growing. Originally the 3-D printer was looked at as a fancy toy builder or even a expensive parlor trick but now people are seeing more than just shapes and parts, now scientist are trying to make limbs and even organs. Printing new body parts is a great way for people who have lost or were born without limbs to gain some function back that can be more comfortable and, with the technology of 3-D printing growing, more cost effective. But an advancement that has been a desire and has been out of the grasp of scientist is to create donor organs.
                With approximately 120,000 people on a wait-list for a lifesaving organ transplant and another name adding every 10 min the need for this advancement is obvious how to go about it is something that’s been a difficulty for scientist. Until two weeks ago, when a group of scientist at the University of California San Diego lead by nano-engineering professor Shaochen Chen created the first vasculature made by a 3-D printer. The vasculature in the body is the arrangement or the distribution of blood vessels in an organ or body part that can transport blood, nutrients, waste and other material through the body. Until now the only thing that 3-D printing could make was simple tubes and valves which cannot be integrated with the body. This new system is a quicker and more cost-effective way of making blood vessels and other parts, it starts by taking 2-D pictures of the biological structure and transfers it to a computer where it is transferred into a 3-D structure that can be used. While this is not a fully man made organ that could save the on average 22 people that die every day waiting on the transplant list this is a huge step in that direction. The importance of this is highlighted by Professor Chen when he said, “Almost all tissues and organs need blood vessels to survive and work properly. This is a big bottleneck in making organ transplants, which are in high demand but in short supply…., 3-D bioprinting organs can help bridge this gap…”. This advance could mean so much to people and their families waiting for a transplant.

                The article I read was absolutely amazing the more I think about it. This advancement hit pretty close to home because my Grandfather had kidney failure and didn’t want to receive kidney from anyone especially family, he was worried that there was a chance that the kidney failure would pass to his children. But with this discovery it could leave out the need for someone to lose one of their kidneys or part of their liver it would be something made specifically for the person and would save thousands if not millions of lives. 

8 comments:

  1. 3D printing of organs is a topic that really intrigues me! Your personal experience with your grandpa helped me to see one reason why 3D organ printing would be a beneficial advancement! I remember researching this topic and watching Youtube videos on 3D organ printing a few months ago. One of the major issues with organ donation is possibility of rejection. Since the patients own cells are used to create a 3D organ there would be no cause for organ rejection! That's a very significant advancement! RS

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  2. I find your article chosen very interesting. One of my brothers is an engineer, and he has his 3D printer at home. So I was aware of what 3D printing is, but I had no idea about 3D printing organs. That is just amazing. I do see how this could help all of those 120 000 people that need an organ transplant. So, is there an estimate of a time frame that will take until this is a possibility? What are some of the other encountering difficulties that scientists have to go through so 3D printing of organ can be finally practiced?
    -Tanee

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    1. Tanee great questions! Dr. Stephen Badylak is one of the leading scientists of regenerative medicine. The science behind growing organs or "printing" them is already in the works. He has already regrown fingers, helped military vets heal and has been working on using scaffolds to regrow organs that have gone bad in individuals using Extracellular Matrix (ECM). I highly recommend you look him up! The issues they are currently running into is creating a warm incubative environment for these organs to grow and successfully replace the bad organs in the people needing them.

      -MJ

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  4. I really enjoyed this article. I have never really thought about how we can make artificial organs. I always just assumed that an organ had to be from another person. When this comes out, I agree, it will save many lives. For there are like you said many people on the waiting list and passing away because there are not many organs available.

    -DP

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  5. I have been hearing more and more about this topic lately, and as interesting as it is, I am also very confused. My question for this topic is, what on earth are these 3D organs made out of so that they properly function in the body? How does the body not see it as a foreign object and want to attack it? Our body specially makes everything in it, and its all made up up our own tissue. So what kinds of material is being printed so that it functions in the body and is not rejected?

    Lindsey Tanner

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    1. Lindsey, I also have a few questions. Like how can the body not reject the 3-D printed organ and how can it even work? Because printing 3-D is just plastic. ABS plastic, PLA, polyamide (nylon), glass filled polyamide, stereolithographic materials (epoxy resins), silver, titanium, steel, wax, photopolymers and polycarbonate to be exact. How can the actual body accept it and use it? Considering also that our organs need to move and flex to work, how can this expensive piece of plastic work? But after researching, I came across and article that explains exactly that. (https://3dprint.com/119885/wake-forest-3d-printed-tissue/) in the article it explains how they have already practiced implanting 3-D printed ears, bone, and muscle structure in animals. After implanted the body need to adjust to the new addition but then once matured in the body and accepted, the body attaches on to it and forms it into human tissue! They form blood vessels systems into it and around it. In conclusion, the body is amazing and although we can’t comprehend this happening. The body is wiser and does the miracle itself. Hopefully that answered your question! Best of luck to ya!
      -HH

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  6. I like how 3-D printing could prevent mortalities from people whose lives rely on organs taken from dead or alive humans. People would no longer die because they waited too long for an organ transplant. It interests me that engineered mechanical material is able to make living organisms that perform the same complex functions that a human body performs. I feel that the ability of making organisms from mechanical machines opens opportunities to alter or add organisms to assist in other health problems such as a replacement of a non-functioning pancreases in a diabetic patient.
    A.B

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